Work

Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy

Year: 2008

Type: article

Abstract: We have developed a global strategy based on the Bayesian network framework to prioritize the functional modules mediating genetic perturbations and their phenotypic effects among a set of overlapping candidate modules. We take lethality in Saccharomyces cerevisiae and human cancer as two examples to show the effectiveness of this approach. We discovered that lethality is more conserved at the module level than at the gene level and we identified several potentially 'new' cancer-related biological processes.

Source: Genome biology

DOI: 10.1186/gb-2008-9-12-r174

Authors: Li Wang, Fengzhu Sun, Ting Chen

Institutions: University of Southern California, Tsinghua University

Language: English

Topic: Bioinformatics and Genomic Networks

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,490