Work

Persistent Problems with Persistent Disease: Minimal Residual Disease in Acute Myelogeous Leukemia

Year: 2013

Type: article

Abstract: Unlike acute lymphoblastic leukemia in children, the presence, significance, and management of minimal residual disease (MRD) in acute myelogeous leukemia (AML) are complex, controversial, and not clearly defined [1,2]. AML is not a single disease, but rather a heterogeneous collection of diseases with characteristic recurrent cytogenetic and/or molecular genetic abnormalities that lead to an arrest of myeloid differentiation. Although many of the mutations, duplications, and translocations that contribute to the development of AML are known, some patients have a normal karyotype and no routinely identifiable genetic aberration.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.12.009

Authors: Eytan M. Stein, Martin S. Tallman

Institutions: Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650