Work

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

Year: 2013

Type: review

Abstract: Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.

Source: Cell

DOI: 10.1016/j.cell.2013.07.011

Authors: Geeta J. Narlikar, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes

Institutions: University of California, San Francisco, University of Dundee

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $5,213

Funder: Wellcome Trust