Work

Two-Photon Luminescence Imaging of Cancer Cells Using Molecularly Targeted Gold Nanorods

Year: 2007

Type: article

Abstract: We demonstrate the use of gold nanorods as bright contrast agents for two-photon luminescence (TPL) imaging of cancer cells in a three-dimensional tissue phantom down to 75 mum deep. The TPL intensity from gold-nanorod-labeled cancer cells is 3 orders of magnitude brighter than the two-photon autofluorescence (TPAF) emission intensity from unlabeled cancer cells at 760 nm excitation light. Their strong signal, resistance to photobleaching, chemical stability, ease of synthesis, simplicity of conjugation chemistry, and biocompatibility make gold nanorods an attractive contrast agent for two-photon imaging of epithelial cancer.

Source: Nano Letters

DOI: 10.1021/nl062962v

Authors: Nicholas J. Durr, Timothy Larson, Danielle K. Smith, Brian A. Korgel, Konstantin Sokolov, Adela Ben-Yakar

Institutions: The University of Texas MD Anderson Cancer Center, Texas Materials Institute, The University of Texas at Austin

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, Division of Chemistry