Work

Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells

Year: 2007

Type: article

Abstract: Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

Source: Journal of Bacteriology

DOI: 10.1128/jb.01153-06

Authors: Heather C. Maisey, Mary Hensler, Victor Nizet, Kelly S. Doran

Institution: University of California San Diego

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green