Work

Queenslandon, a New Antifungal Compound Produced by Chrysosporium queenslandicum: Production, Isolation and Structure Elucidation.

Year: 2002

Type: article

Abstract: In the course of our screening program for biologically active compounds from pathogenic microorganisms, an antibacterial and antifungal naphthoquinone group antibiotic complex was isolated from the culture broth of a strain Chrysosporium queenslandicum IFM 51121.The compounds of the complex were identified as altersolanol A, B and C1-3).Besides the antibiotics, the strain C. queenslandicum IFM 51121 produces also a new antifungal compound related to zearalenone family of mycotoxin4), designated queenslandon (1).In this paper we report the production, isolation and structure elucidation of the mycotoxin queenslandon (Fig. 1), through the use of one and two dimensional NMR techniques and mass-spectrometry.C. queenslandicum IFM 51121 strain was isolated from a soil sample collected in Egypt, and deposited in the collection of Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.The mature slant culture of C. queenslandicum IFM 51121 was inoculated into a 50ml Erlenmeyer shake flask containing 25ml of a seed medium (2% glucose supplemented BHI medium).The inoculated flask was

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.55.516