Work

Cell fate conversion by mRNA

Year: 2011

Type: article

Abstract: Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researchers and clinicians alike. It is hoped that this technology could contribute to unmet needs on several fronts of regenerative medicine, including mechanistic study of reprogramming, generation of safe induced pluripotent stem cells suitable for clinical applications, and derivation of desired cell types for cell-replacement therapy. We will discuss the technological advancements made by this synthetic mRNA methodology, its implications, as well as the challenges that lie ahead in the field of regenerative medicine.

Source: Stem Cell Research & Therapy

DOI: 10.1186/scrt46

Authors: Mo Li, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte

Institutions: Salk Institute for Biological Studies, Center of Regenerative Medicine in Barcelona

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190