Work

Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

Year: 2005

Type: article

Abstract: The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.43.1.464-467.2005

Authors: Jill R. Blankenship, Nina Singh, Barbara D. Alexander, Joseph Heitman

Institutions: VA Pittsburgh Healthcare System, Duke Medical Center, Howard Hughes Medical Institute

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, Burroughs Wellcome Fund, National Institutes of Health, National Institute of Allergy and Infectious Diseases