Cut-off Value of 50-g Glucose Challenge Test for The Diagnosis of Gestational Diabetes Mellitus
Year: 2013
Type: article
Study design: Observational Study
Abstract: Objective: To determine the cut-off value of 50-g glucose challenge test (GCT) for the diagnosisof gestational diabetes mellitus (GDM) among Thai pregnant women.Materials and Methods: A study was conducted at the Department of Obstetrics and Gynecology,Faculty of Medicine Siriraj Hospital. Data of 816 pregnant women who were at risk for GDMwith abnormal 50-g GCT results (≥140 mg/dL) before 20 weeks of gestation were included. Allwomen received 100-g oral glucose tolerance test (OGTT) for GDM diagnosis. This approachwas repeated during 24-28 weeks of gestation among those with normal 100-g OGTT results.Medical records were reviewed for data collection. Positive predictive values for GDM diagnosiswere estimated at different cut-off levels of 50-g GCT, using 10 mg/dL increment interval.Results: Mean age was 32.4±5.1 years, and mean gestational age when 50-g GCT was initiallyperformed was 10.1±5.9 weeks of gestation. GDM was diagnosed in 290 cases (35.5%) andmean gestational age at diagnosis was 19.1±10.3 weeks. The positive predictive values forGDM diagnosis increased with 50-g GCT values. Of 19 and 13 women whose 50-g GCT valueswere ≥230 and ≥240 mg/dL, 90.5% and 100% were diagnosed with GDM, respectively.Conclusion: 50-g GCT before 20 weeks of gestation could be applied and used for diagnosis ofGDM using appropriate cut-off value.
Institutions: Siriraj Hospital, Mahidol University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $100
OpenAlex ID: W2119930399