Work

The growth-associated protein B-50 (GAP-43) in dystrophic neurites extending into Alzheimer's plaques

Year: 1993

Type: article

Abstract: The expression of the growth associated protein B-50 (GAP-43) is developmentally regulated and reinduced following neuronal injury. Using B-50 as marker for sprouting in single and double immunolabeling of neocortex of Alzheimer's disease (AD) we demonstrate that bulbous B-50 immunoreactive dystrophic neurites are found in β-amyloid/A4 positive plaques. Our results and those of others indicate that dystrophic neurites contain B-50 implicating this protein in the disease induced response.

Source: Utrecht University Repository (Utrecht University)

Authors: W.H. Gispen, A.B. Oestreicher, Annemieke J.M. Rozemüller

Institution: Utrecht University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2119989760

FWCI: 0.761

Cites:

Cited by: 17

Related to: 10