Work

Respected Sir(2): magic target for diabetes.

Year: 2008

Type: article

Abstract: The endless quest for the 'fountain of youth' has led to the discovery of a family of molecules known as sirtuins in humans, or silent mating type information regulator 2 (Sir2) in yeast, which are associated with longevity in yeast, nematodes, drosophila and rodents. Although sirtuins have yet to be proven to delay aging and promote longevity in humans, they promise 'healthy aging', an ideal of modern society. This review emphasizes the role of various sirtuins in maintaining glucose homeostasis, the therapeutic potential of sirtuin modulators in the prevention and treatment of diabetes, and the emerging associations of SIRT genetic polymorphisms with human longevity.

Source: PubMed

Authors: Pratibha V Nerurkar, Vivek R Nerurkar

Institutions: University of Hawaiʻi at Mānoa, University of Hawaii System

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Center for Research Resources, National Institute on Minority Health and Health Disparities, National Center for Complementary and Integrative Health

Awards: RCMI CLINICAL RESEARCH INFRASTRUCTURE INITIATIVE (RCRII), Bioscience Research Infrastructure Development for Grant Enhancement and Success, Longevity foods, SIRT activation and diabetic dyslipidemia., The Center for Native and Pacific Health Disparities Research