Work

Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis

Year: 2007

Type: review

Abstract: Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.

Source: Annual Review of Microbiology

DOI: 10.1146/annurev.micro.61.080706.093426

Authors: Rita Tamayo, Jason T. Pratt, Andrew Camilli

Institutions: Tufts University, Howard Hughes Medical Institute

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases