Work

The Phe-Phe Motif for Peptide Self-Assembly in Nanomedicine

Year: 2015

Type: review

Abstract: Since its discovery, the Phe-Phe motif has gained in popularity as a minimalist building block to drive the self-assembly of short peptides and their analogues into nanostructures and hydrogels. Molecules based on the Phe-Phe motif have found a range of applications in nanomedicine, from drug delivery and biomaterials to new therapeutic paradigms. Here we discuss the various production methods for this class of compounds, and the characterization, nanomorphologies, and application of their self-assembled nanostructures. We include the most recent findings on their remarkable properties, which hold substantial promise for the creation of the next generation nanomedicines.

Source: Molecules

DOI: 10.3390/molecules201119658

Authors: Silvia Marchesan, Attilio Vargiu, Katie Styan

Institutions: University of Trieste, University of Cagliari, Commonwealth Scientific and Industrial Research Organisation, CSIRO Manufacturing

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funder: Ministero dell’Istruzione, dell’Università e della Ricerca