Work

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

Year: 2008

Type: article

Abstract: Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG–phospholipid micelle were prepared (see scheme; PEG=poly(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual-mode imaging of tumor tissues by near-infrared fluorescence and NMR spectroscopy.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200801810

Authors: Ji‐Ho Park, Geoffrey von Maltzahn, Erkki Ruoslahti, Sangeeta N. Bhatia, Michael J. Sailor

Institutions: University of California San Diego, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, University of California, Santa Barbara

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Public Health Service, National Heart, Lung, and Blood Institute, National Cancer Institute