Work

Depth resolved detection of lipid using spectroscopic optical coherence tomography

Year: 2013

Type: article

Abstract: Optical frequency domain imaging (OFDI) can identify key components related to plaque vulnerability but can suffer from artifacts that could prevent accurate identification of lipid rich regions. In this paper, we present a model of depth resolved spectral analysis of OFDI data for improved detection of lipid. A quadratic Discriminant analysis model was developed based on phantom compositions known chemical mixtures and applied to a tissue phantom of a lipid-rich plaque. We demonstrate that a combined spectral and attenuation model can be used to predict the presence of lipid in OFDI images.

Source: Biomedical Optics Express

DOI: 10.1364/boe.4.001269

Authors: Christine P. Fleming, Jocelyn Eckert, Elkan F. Halpern, Joseph A. Gardecki, Guillermo J. Tearney

Institutions: Columbia University, Massachusetts General Hospital

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,913