Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma
Year: 2014
Type: review
Abstract: Regional metastasis is a prominent feature of head and neck squamous cell carcinoma (HNSCC) and is an important prognostic factor. The currently available imaging techniques for assessment of the neck have limitations in accuracy; thus, elective neck dissection has remained the usual choice of management of the clinically N0 neck (cN0) for tumors with significant (≥20%) incidence of occult regional metastasis. As a consequence, the majority of patients without regional metastasis will undergo unnecessary treatment. The purpose of this review was to discuss new developments in techniques that potentially improve the accuracy of the assessment of the neck in patients with HNSCC. Although imaging has improved in the last decades, a limitation common to all imaging techniques is a lack of sensitivity for small tumor deposits. Therefore, complementary to improvements in imaging techniques, developments in more invasive diagnostic procedures, such as sentinel node biopsy (SNB) will add to the accuracy of diagnostic algorithms for the staging of the neck.
Source: Head & Neck
DOI: 10.1002/hed.23814
Authors: Remco de Bree, Robert P. Takes, Jonas A. Castelijns, Jesus E. Medina, Sandro J. Stoeckli, Anthony A. Mancuso, Jennifer L. Hunt, Juan P. Rodrigo, Asterios Triantafyllou, Afshin Teymoortash, Francisco J. Civantos, Alessandra Rinaldo, Karen T. Pitman, Marc Hamoir, K. Thomas Robbins, Carl E. Silver, Otto S. Hoekstra, Alfio Ferlito
Institutions: Amsterdam UMC Location Vrije Universiteit Amsterdam, Radboud University Medical Center, Gemeente Amsterdam, University of Oklahoma Health Sciences Center, Kantonsspital St. Gallen, University of Florida Health, University of Florida, University of Arkansas for Medical Sciences, Hospital Universitario Central de Asturias, University of Liverpool, Philipps University of Marburg, University of Miami, Sylvester Comprehensive Cancer Center, University of Udine, Banner MD Anderson Cancer Center, Cliniques Universitaires Saint-Luc, SIU Medicine, Albert Einstein College of Medicine, Montefiore Medical Center
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2120264692