Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Year: 2010
Type: review
Abstract: The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, anxiety, depression, and schizophrenia.
Authors: Colleen M. Niswender, P. Jeffrey Conn
Institution: Vanderbilt University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence, Partial Antagonists of mGluR5 for Treatment of Cocaine Addiction, The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Functional effects of mGluR potentiators in the CNS, Regulation of Signaling by mGluR5, Functions of Metabotropic Glutamate Receptor Subtypes
OpenAlex ID: W2120307371