Work

FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster

Year: 2006

Type: review

Abstract: SUMMARY: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

Source: Bioinformatics

DOI: 10.1093/bioinformatics/btl143

Authors: Boris Adryan, Sarah A. Teichmann

Institution: MRC Laboratory of Molecular Biology

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,989

Funder: Medical Research Council