Work

Deciphering the role of natural variation in age-related protein homeostasis

Year: 2013

Type: article

Abstract: Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.See research article: http://www.biomedcentral.com/1741-7007/11/100.

Source: BMC Biology

DOI: 10.1186/1741-7007-11-102

Author: Matt Kaeberlein

Institution: University of Washington

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,690