Work

CD4+ T-Lymphocyte Depletion in Human Lymphoid Tissue Ex Vivo Is Not Induced by Noninfectious Human Immunodeficiency Virus Type 1 Virions

Year: 1998

Type: article

Abstract: We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection.

Source: Journal of Virology

DOI: 10.1128/jvi.72.11.9345-9347.1998

Authors: A. W. Sylwester, J.-C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, L. B. Margolis

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Science Applications International Corporation (United States)

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute