New insights into the pathology of pulmonary hypertension: implication of the miR‐210/ISCU1/2/Fe‐S axis
Year: 2015
Type: article
Abstract: Elevated pulmonary arterial pressure in patients with pulmonary hypertension (PH) is mainly caused by increased pulmonary vascular resistance (PVR), due primarily to sustained pulmonary vasoconstriction and excessive pulmonary vascular remodeling. According to the current classification, PH has been classified into five categories based on etiology (Simonneau et al, 2013). Among them, group 1 or pulmonary arterial hypertension (PAH) is a rare but progressive and deadly disease affecting ~1–10 per 1 million people. Despite expanding treatment options to ameliorate patients' symptoms, PAH remains a devastating disease with a poor long‐term prognosis.
Source: EMBO Molecular Medicine
Authors: Haiyang Tang, Ramon J Ayon, Jason X‐J Yuan
Institution: University of Arizona
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $7,990
Awards: G1194350049, Molecular mechanisms of hypoxia tolerance and susceptibility, G1622472627, G1717768068, Molecular mechanisms of downregulated Kv channels in IPAH: Role of microRNA, Calcium Signaling in Pulmonary Arterial Hypertension: Role of CaSR and TRPC6, G46212086, Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertension
OpenAlex ID: W2120675651