Session III: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes
Year: 2012
Type: article
Abstract: There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Mechanism for Altered Synaptic Function During Aging, UF Clinical and Translational Science Award, Signaling cascades and memory deficits during aging, Hippocampal Electrophysiology and Myelinogenesis in Healthy Cognitive Aging, ALZHEIMERS RESEARCH PROJECT: Neuroimaging Predictors of Alzheimer's Disease and Cognitive Decline, University of Florida Older Americans Independence Center (OAIC)
OpenAlex ID: W2120728912