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Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains

Year: 2009
Type: article
Abstract: We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
DOI: 10.1128/aac.01415-08
Authors: Soo-Jin Yang, Yan Q. Xiong, Paul M. Dunman, Jacques Schrenzel, Patrice François, Andreas Peschel, Arnold S. Bayer
Institutions: University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center, University of Nebraska Medical Center, University Hospital of Geneva, University of Tübingen
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2120786299
FWCI: 7.336
Cites: 17
Cited by: 101
Related to: 10