Work

Food reinforcement, the dopamine D₂ receptor genotype, and energy intake in obese and nonobese humans.

Year: 2007

Type: article

Abstract: The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.

Source: Behavioral Neuroscience

DOI: 10.1037/0735-7044.121.5.877

Authors: Leonard H. Epstein, Jennifer L. Temple, Brad J. Neaderhiser, Robbert J. Salis, Richard W. Erbe, John J. Leddy

Institution: University at Buffalo, State University of New York

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development