Work

The expanding implications of polyploidy

Year: 2015

Type: review

Abstract: Polyploid cells, which contain more than two genome copies, occur throughout nature. Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also promote nonuniform genome, transcriptome, and metabolome alterations. Polyploidy also frequently confers resistance to environmental stresses not tolerated by diploid cells. Recent progress has begun to unravel how this fascinating phenomenon contributes to normal physiology and disease.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201502016

Authors: Kevin P. Schoenfelder, Donald T. Fox

Institution: Duke Medical Center

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: National Institute of General Medical Sciences

Awards: Organization and Function of Cellular Structure, Genetics Training Grant