HIV Infection and Aging Independently Affect Brain Function as Measured by Functional Magnetic Resonance Imaging
Year: 2010
Type: article
Study design: Observational Study
Abstract: We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.
DOI: 10.1086/649899
Institution: Washington University in St. Louis
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: National Institutes of Health, Center for AIDS Research, University of Washington, University of California, San Diego, National Institute of Mental Health, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: G1202121545, G1239670587, G1673554580, G1812340134, G2132829350, G2202404319, G2344635089, G25173860, G2644244698, G2949335559, CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER), G3249837921, THE EFFECTS OF AGE AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON BRAIN FUNCTION, G33819333, G3503648764, G3611395682, G4632628815, G473273920, G5466456334, G548982221, G5816822016, G6427914508, G645235059, G6464879405, Compartmentalization of HIV within the genital tract, G6875037537, Calibrated BOLD fMRI of HIV Associated Neurocognitive Impairment (HNCI), G724937252, Washington University Institute of Clinical and Translational Sciences, G9000027917, G9000031394, G9000096674, G9000133637, G9000133689, G9000173005, G9000304622, G9000307584, G9000350240, San Diego Center for AIDS Research (SD CFAR), HIV Neurobehavioral Research Center
OpenAlex ID: W2120891244