Work

Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients.

Year: 1996

Type: article

Abstract: With the concept that the persistence of donor leukocyte chimerism plays a seminal role in the acceptance of whole organ allografts,1–4 we initiated a prospective trial in December 1992 to enhance chimerism by adjuvant infusion of unmodified donor bone marrow (BM) in liver, kidney, and thoracic organ recipients.5 Conventional tacrolimus/prednisone immunosuppression was given without any kind of recipient preconditioning. We report the outcome of the first 34 liver transplantations, along with 29 contemporaneous control cases in which permission could not be obtained for BM removal from the cadaveric liver donors.

Source: PubMed