Work

An XML message broker framework for exchange and integration of microarray data

Year: 2003

Type: article

Abstract: MOTIVATION: Microarrays are an important research tool for the advancement of basic biological sciences. However this technology has yet to be integrated with clinical decision making. We have implemented an information framework based on the Microarray Gene Expression Markup Language (MAGE-ML) specification. We are using this framework to develop a test-bed integrated database application to identify genomic and imaging markers for diagnosis of breast cancer. RESULTS: We developed extensible software architecture for retrieving data from different microarray databases using MAGE-ML and for combining microarray data with breast cancer image analysis and clinical data for correlation studies. The framework we developed will provide the necessary data integration to move microarray research from basic biological sciences to clinical applications. AVAILABILITY: Open source software will be available from SourceForge (http://sourceforge.net/projects/microsoap/).

Source: Bioinformatics

DOI: 10.1093/bioinformatics/btg246

Authors: Donny Tjandra, Stephen Wong, Weimin Shen, Brian Pulliam, Elaine Yu, Laura Esserman

Institutions: University of California, San Francisco, University of California San Francisco Medical Center, Brigham and Women's Hospital, Harvard University, University of California System

Language: English

Topic: Gene expression and cancer classification

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2121063860

FWCI: 0.575

Cites: 3

Cited by: 5

Related to: 10