The role of CTCF in regulating nuclear organization
Year: 2008
Type: article
Abstract: The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.
DOI: 10.1084/jem.20080066
Authors: Adam Williams, Richard A. Flavell
Institutions: Howard Hughes Medical Institute, Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Howard Hughes Medical Institute
OpenAlex ID: W2121082482