Work

Disparity in the In Vitro versus In Vivo Regulation of Fibronectin‐Binding Proteins by 2 Global Regulators,saeRSandsigB, inStaphylococcus aureus

Year: 2009

Type: article

Abstract: Fibronectin-binding protein A plays an important role in Staphylococcus aureus endovascular infections. We characterized the sigB-saeRS-fnbA expression network with fibronectin binding in vitro and in an experimental infective endocarditis (IE) model using parental strains RN6390 and SH1000 and their respective isogenic saeRS mutants. In contrast to the in vitro data, there was no influence of saeRS on fnbA expression in the IE model, yet ex vivo fibronectin binding was reduced in saeRS mutants. Moreover, as opposed to the in vitro findings, sigB appeared to have a positive rather than a negative effect on saeRS expression within cardiac vegetations.

Source: The Journal of Infectious Diseases

DOI: 10.1086/606011

Authors: Ambrose L. Cheung, Soo‐Jin Yang, Arnold S. Bayer, Yan Q. Xiong

Institutions: Dartmouth College, Dartmouth Health, The Lundquist Institute, Harbor–UCLA Medical Center, University of California, Los Angeles

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Institute of Allergy and Infectious Diseases