Work

In vitro activity of Bay 12-8039, a new 8-methoxyquinolone

Year: 1997

Type: article

Abstract: MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-fold more active than ciproiloxacin and ofloxacin against nonfermenters (except P. aeruginosa), staphylococci, streptococci, enterococci, and anaerobes. As determined by regression analysis, there was a high degree of correlation among quinolone MICs.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.41.8.1818

Author: R J Fass

Institutions: The Ohio State University Wexner Medical Center, The Ohio State University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2121104646

FWCI: 6.32

Cites: 9

Cited by: 79

Related to: 10