Work

Propofol and sevoflurane induce distinct burst suppression patterns in rats

Year: 2014

Type: article

Abstract: Burst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ among general anesthetics.

Source: Frontiers in Systems Neuroscience

DOI: 10.3389/fnsys.2014.00237

Authors: Jonathan D. Kenny, M. Brandon Westover, ShiNung Ching, Emery N. Brown, Ken Solt

Institutions: Massachusetts General Hospital, Harvard University, Washington University in St. Louis, Massachusetts Institute of Technology

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801