Work

Understanding How Cells Allocate Metals Using Metal Sensors and Metallochaperones

Year: 2005

Type: review

Abstract: Each metalloprotein must somehow acquire the correct metal. We review the insights into metal specificity in cells provided by studies of ArsR-SmtB DNA binding, metal-responsive transcriptional repressors, and a bacterial copper chaperone. Cyanobacteria are the one bacterial group that have known enzymatic demand for cytoplasmic copper import. The copper chaperone and ATPases that supply cyanobacterial plastocyanin and cytochrome oxidase are reviewed, along with related ATPases for cobalt and zinc. These studies highlight the contributions of protein-protein interactions to metal speciation. Metal sensors and metallochaperones, along with metal transporters and metal-storage proteins, act in concert not only to supply the correct metals but also to withhold the wrong ones.

Source: Accounts of Chemical Research

DOI: 10.1021/ar0300118

Authors: Stephen Tottey, Duncan R. Harvie, Nigel J. Robinson

Institution: Newcastle University

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

Open Access status: green

Funder: Biotechnology and Biological Sciences Research Council

Award: G395309054