Work

A Critical Examination of the “Bad Luck” Explanation of Cancer Risk

Year: 2015

Type: article

Abstract: Tomasetti and Vogelstein (1) argue that lifetime cancer risk for particular tissues is mostly determined by the total number of stem cell (SC) divisions within the tissue, whereby most cancers arise due to “bad luck”—mutations occurring during DNA replication. We argue that the poorly substantiated estimations of SC division parameters and assumptions that oversimplify somatic evolution prevent such a conclusion from being drawn. Cancer Prev Res; 8(9); 762–4. ©2015 AACR. See related article by Wang et al., p. 761

Source: Cancer Prevention Research

DOI: 10.1158/1940-6207.capr-15-0229

Authors: Andrii I. Rozhok, Geoffrey M. Wahl, James DeGregori

Institutions: University of Colorado Anschutz, University of Colorado Denver, Salk Institute for Biological Studies

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute