Work

Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

Year: 2014

Type: article

Abstract: OBJECTIVE: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD). METHODS: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls. CONCLUSION: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

Source: Brazilian Journal of Psychiatry

DOI: 10.1590/1516-4446-2014-1380

Authors: Izabela G. Barbosa, Isabela B. Morato, Rodrigo B. Huguet, Fabio L. Rocha, Rodrigo Machado-Vieira, Antônio L. Teixeira

Institutions: Universidade Federal de Minas Gerais, Universidade de São Paulo

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais