Work

Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data

Year: 2003

Type: conference-abstract

Abstract: Informative missingness of parental genotype data occurs when the genotype of a parent influences the probability of the parent's genotype data being observed. Informative missingness can occur in a number of plausible ways and can affect both the validity and power of procedures that assume the data are missing at random (MAR). We propose a bootstrap calibration of MAR procedures to account for informative missingness and apply our methodology to refine the approach implemented in the TRANSMIT program. We illustrate this approach by applying it to data on hypertensive probands and their parents who participated in the Framingham Heart Study.

Source: BMC Genetics

DOI: 10.1186/1471-2156-4-s1-s39

Authors: Andrew S Allen, Julianne S Collins, Paul J Rathouz, Craig L Selander, Glen A Satten

Institutions: Duke University, Duke Clinical Research Institute, Greenwood Genetic Center, University of Chicago, Centers for Disease Control and Prevention, National Center for Environmental Health

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,170

OpenAlex ID: W2121472536

Cites: 9

Cited by: 6

Related to: 10