The journey from stem cell to macrophage
Year: 2014
Type: review
Abstract: Essential protectors against infection and injury, macrophages can also contribute to many common and fatal diseases. Here, we discuss the mechanisms that control different types of macrophage activities in mice. We follow the cells' maturational pathways over time and space and elaborate on events that influence the type of macrophage eventually settling a particular destination. The nature of the precursor cells, developmental niches, tissues, environmental cues, and other connecting processes appear to contribute to the identity of macrophage type. Together, the spatial and developmental relationships of macrophages compose a topo-ontogenic map that can guide our understanding of their biology.
DOI: 10.1111/nyas.12393
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Imaging of Cardiac Transplant Rejection, Center for Molecular Imaging Research at MGH/HMS, In vivo behavior of monocytes in resting and inflammatory conditions, G4479692847, Innate Response Activator B cells in Bacterial Lung Infection, G5816946255, PET/MRI of cardiac repair, Monocyte and macrophage Behavior in Atherosclerosis, Tumor-Stroma Interacions in the Tumor Microenvironment
OpenAlex ID: W2121517562