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Light chain disease associated with the hyperviscosity syndrome

Year: 1987

Type: article

Abstract: The hyperviscosity syndrome refers to a group of symptoms and signs related to increased blood viscosity often produced by monoclonal immunoglobulins. It is most frequently associated with Waldenström's macroglobulinemia and, on occasion, with other immunoglobulins that are capable of forming highly polymerized molecules. This article is a report on the first case of pure light chain myeloma associated with the hyperviscosity syndrome. The hyperviscous plasma in this case is secondary to the unusual degree of aggregation of kappa light chain as demonstrated by high-resolution electrophoresis, serum immunofixation, and Sephadex g-200 (Pharmacia, Piscataway, NJ) column chromatography.

Source: Cancer

DOI: 10.1002/1097-0142(19871101)60:9<2267::aid-cncr2820600927>3.0.co;2-4

Authors: Parvez Khan, Mark S. Roth, David F. Keren, Kenneth A. Foon

Institutions: University of Michigan, Michigan Medicine, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2121607794

FWCI: 0.226

Cites: 12

Cited by: 20

Related to: 10