Work

In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides

Year: 2001

Type: article

Abstract: The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.45.11.3209-3212.2001

Authors: Gudmundur Bergsson, Jóhann Arnfinnsson, Ólafur Steingrı́msson, Halldor Thormar

Institutions: University of Iceland, National University Hospital of Iceland

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2121791697

FWCI: 1.686

Cites: 14

Cited by: 289

Related to: 10