Work

Human melanotransferrin (p97) has only one functional iron‐binding site

Year: 1992

Type: article

Abstract: The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling. These show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule. The binding properties of its N-terminal site are similar to other transferrins, but its C-terminal site does not bind iron at all. The differences can be related to specific amino acid changes in the C-terminal site.

Source: FEBS Letters

DOI: 10.1016/0014-5793(92)80060-t