Year: 2009
Type: article
Abstract: Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
DOI: 10.1093/jmcb/mjp019
Authors: W. W.-L. Wong, J. Silke
Institution: La Trobe University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2071108458