Year: 2002
Type: article
Abstract: AnimalsUse Sexually Mature Animals, Whenever Practical, for Evaluating Effects on Spermatogenesis.Unless the objective of the study dictates otherwise, screening studies in rodents should be conducted in animals that are sexually mature at termination of the study (>9 weeks in rat, >7 weeks in mouse).Ideally dogs should be 9-12 months of age at termination, to minimize confounding aspects of immaturity.If younger animals are used and equivocal results occur, it may be necessary to repeat the study in older animals.The difficulties in obtaining sexually mature primates and the associated handling hazards for laboratory personnel generally preclude their use in screening studies and therefore preclude assessment of treatment-related effects on spermatogenesis.For suspected testicular toxicants, specific studies in sexually mature animals should be considered (4-5 years of age for cynomolgous). Tissue SamplingSample Both Testes and Epididymides, Identify Left and Right Separately and Record Organ Weights.Distinction of unilateral from bilateral effects is important for eval-
Source: Toxicologic Pathology
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2121922155