Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations
Year: 2014
Type: article
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
Source: Schizophrenia Bulletin
Institutions: University of London, Maastricht University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Yale University, Ankara Universitesi, Queen Mary University of London, Wellcome Trust, Royal College of Surgeons in Ireland, Fondation FondaMental, National Institute for Health and Care Research, King's College London, European Commission, Cardiff University, Institut National de la Santé et de la Recherche Médicale, Rijksuniversiteit Groningen, Universiteit van Amsterdam, Vrije Universiteit Amsterdam, Universiteit Maastricht, Gentofte Hospital, Universität Wien, Rivierduinen, Universitair Ziekenhuis Gent, Euskal Herriko Unibertsitatea, University of Hong Kong, KU Leuven, Orta Doğu Teknik Üniversitesi, Universiteit Gent, Università degli Studi di Palermo, National and Kapodistrian University of Athens, Universidade de São Paulo, Universitat de Barcelona, Medizinische Universität Wien, Università di Bologna, Universidad de Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, Universidad de Zaragoza, Università degli Studi di Verona, Universität zu Köln, Universitat Autònoma de Barcelona, Universidad de Deusto, University of North Carolina at Greensboro, Medical Research Council, Economic and Social Research Council
Awards: Psychosis risk over the life course: A multilevel, longitudinal investigation of social, economic and physical environmental risk factors at different stages in life., G26586934, G3154198568, G5144943808, G534012355, G6680420078, Childhood adversity, stress sensitivity, and psychosis: an experience sampling study, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions
OpenAlex ID: W2122020392