Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment
Year: 2012
Type: review
Abstract: Physical factors in the local cellular microenvironment, including cell shape and geometry, matrix mechanics, external mechanical forces, and nanotopographical features of the extracellular matrix, can all have strong influences on regulating stem cell fate. Stem cells sense and respond to these insoluble biophysical signals through integrin-mediated adhesions and the force balance between intracellular cytoskeletal contractility and the resistant forces originated from the extracellular matrix. Importantly, these mechanotransduction processes can couple with many other potent growth-factor-mediated signaling pathways to regulate stem cell fate. Different bioengineering tools and microscale/nanoscale devices have been successfully developed to engineer the physical aspects of the cellular microenvironment for stem cells, and these tools and devices have proven extremely powerful for identifying the extrinsic physical factors and their downstream intracellular signaling pathways that control stem cell functions.
Source: Annual Review of Biophysics
Authors: Yubing Sun, Christopher S. Chen, Jianping Fu
Institutions: University of Michigan, University of Pennsylvania
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, University of Oklahoma, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, Penn Center for Musculoskeletal Disorders
Awards: G1715157081, Mesenchymal Stem Cells and the Microenvironment, G307071764, G3131307667, Michigan Institute for Clinical and Health Research (MICHR) (UL1), G4904070389, Cadherins, integrins, and mechanochemical signaling, Integrated Technologies for Polymeric Biomaterials, RESBIO, Local Regulation of Angiogenesis by Microenvironment
OpenAlex ID: W2122033285