Work

Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

Year: 2014

Type: article

Abstract: A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.

Source: Nanoscale

DOI: 10.1039/c3nr05897b

Authors: Davide Staedler, Thibaud Magouroux, Solène Passemard, Sebastian Schwung, Marc Dubled, Guillaume Stéphane Schneiter, Daniel Rytz, Sandrine Gerber-Lemaire, Luigi Bonacina, Jean-Pierre Wolf

Institutions: École Polytechnique Fédérale de Lausanne, University of Geneva, Forschungsinstitut für Mineralische und Metallische Werkstoffe Edelsteine/Edemetalle, Université Savoie Mont Blanc

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, European Commission, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Award: NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING

OpenAlex ID: W2122044554

FWCI: 1.366

Cites: 44

Cited by: 17

Related to: 10