Work

Human receptors for sweet and umami taste

Year: 2002

Type: article

Abstract: The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5'-ribonucleotides, a hallmark of umami taste. The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.072090199

Authors: Xiaodong Li, Lena Staszewski, Hong Xu, Kyle Durick, Mark Zoller, Elliot Adler

Language: English

Topic: Biochemical Analysis and Sensing Techniques

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2122060463

FWCI: 37.25

Cites: 28

Cited by: 1,412

Related to: 10