Work

Development of microRNA therapeutics is coming of age

Year: 2014

Type: review

Abstract: MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA-based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.

Source: EMBO Molecular Medicine

DOI: 10.15252/emmm.201100899

Authors: Eva van Rooij, Sakari Kauppinen

Institutions: Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht, Hubrecht Institute for Developmental Biology and Stem Cell Research, Aalborg University Hospital, Aalborg University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $7,990