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During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure

Year: 1989

Type: article

Abstract: Latent herpes simplex virus type 1 DNA has a nucleosomal structure similar to that of cellular chromatin, as determined by micrococcal nuclease digestion. All of the major regions, including the transcriptionally active region of the genome, were found to be associated with nucleosomes. Such a chromatin structure is likely to be an important element in the control of herpes simplex virus type 1 gene expression during latency.

Source: Journal of Virology

DOI: 10.1128/jvi.63.2.943-947.1989

Authors: S L Deshmane, N W Fraser

Institution: The Wistar Institute

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke

Award: G6498337413