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A novel dodecadepsipeptide, cereulide, is an emetic toxin of

Year: 1995

Type: article

Abstract: A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.

Source: FEMS Microbiology Letters

DOI: 10.1111/j.1574-6968.1995.tb07550.x

Authors: N AGATA, M OHTA, M MORI, M ISOBE

Institutions: Nagoya City Public Health Research Institute, Nagoya University

Language: English

Topic: Bacillus and Francisella bacterial research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2122538488