Work

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.

Year: 1993

Type: preprint

Abstract: The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.

Source: Genes & Development

DOI: 10.1101/gad.7.7b.1354

Authors: T Fujita, G P Nolan, H C Liou, M L Scott, D Baltimore

Institution: Rockefeller University

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Cancer Research Institute, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: NF-kappaB: Orchestration of the Inflammatory Response, LEUKEMOGENESIS BY ABL AND OTHER ONCOGENES, G581902799